Table 1.
Patient characteristic comparison table. United Network of Organ Sharing, UNOS; Kidney Donor Profile Index, KPDI; Body Mass Index, BMI; Medical University of South Carolina, MUSC; Electronic Health Record, EHR; Length of Stay, LOS; Systolic Blood Pressure, SBP; Myocardial Infarction, MI; Hemoglobin, HGB; Cytomegalovirus, CMV; estimated Glomerular Filtration Rate, eGFR; Inpatient, IP; Emergency Department, ED; Natural Language Processing, NLP; BK virus, BK; Standard Deviation = SD
| Variable | 5Yr Graft Loss (N=265) |
Censored (N=1,174) |
P-value |
|---|---|---|---|
| UNOS | |||
| Age at Transplant (yrs; mean ± SD) | 54 ± 14 | 51 ± 14 | 0.005 |
| Categorical Age at Transplant | 0.005 | ||
| Age <= 40 | 20% | 23% | 0.202 |
| Age = 41–60 | 41% | 47% | 0.049 |
| Age > 60 | 40% | 29% | 0.001 |
| Female | 38% | 40% | 0.428 |
| African American | 57% | 54% | 0.521 |
| Deceased Donor Type | 89% | 83% | 0.018 |
| African American Donor | 33% | 26% | 0.020 |
| KDPI (mean ± SD) | 52 ± 31 | 39 ± 29 | <.001 |
| Categorical KDPI | <.001 | ||
| KDPI = 1% - 20% | 20% | 34% | <.001 |
| KDPI = 21% - 84% | 61% | 60% | 0.633 |
| KDPI = 85% - 100% | 19% | 7% | <.001 |
| Blood Type B | 17% | 16% | 0.708 |
| Waiting Time (Years) | 1.8 ± 1.7 | 1.7 ± 1.6 | 0.337 |
| Delayed Graft Function | 18% | 15% | 0.117 |
| Diabetes | 41% | 34% | 0.033 |
| BMI (mean ± SD) | 28.8 ± 5.7 | 29.0 ± 5.4 | 0.497 |
| Categorical BMI | 0.907 | ||
| BMI < 20 | 5% | 4% | 0.689 |
| BMI = 20–35 | 80% | 81% | 0.732 |
| BMI >= 35 | 15% | 15% | 0.882 |
| Private Insurance | 22% | 28% | 0.072 |
| Distance to MUSC_km (mean ± SD) | 249 ± 172 | 238 ± 196 | 0.358 |
| Categorical Distance to MUSC | 0.295 | ||
| Distance < 80 km | 23% | 26% | 0.399 |
| Distance = 80 – 161 km | 9% | 11% | 0.484 |
| Distance = 161 – 322 km | 38% | 40% | 0.661 |
| Distance >= 322 km | 29% | 23% | 0.063 |
| Previous Kidney Transplant | 11% | 8% | 0.135 |
| Velos+EHR | |||
| Finish High School | 85% | 87% | 0.243 |
| Employed | 25% | 33% | 0.013 |
| Received Disability | 50% | 47% | 0.338 |
| Married | 59% | 62% | 0.480 |
| Smoker | 12% | 6% | 0.001 |
| EHR | |||
| Congestive Heart Failure | 17% | 12% | 0.036 |
| Peripheral Vascular Disorders | 14% | 11% | 0.231 |
| Cerebrovascular Disease | 5% | 6% | 0.644 |
| Cardiac Arrhythmias | 30% | 22% | 0.005 |
| Valvular Disease | 9% | 9% | 0.767 |
| Hypertension | 96% | 96% | 0.931 |
| Alcohol Abuse | 5% | 3% | 0.201 |
| Drug Abuse | 4% | 3% | 0.328 |
| Depression | 13% | 12% | 0.891 |
| Myocardial Infarction | 12% | 5% | <.001 |
| Transplant LOS_Days (mean ± SD) | 4.0 ± 3.9 | 3.4 ± 2.3 | 0.024 |
| Transplant LOS > 3 days | 26% | 20% | 0.057 |
| Acute MI ‡ | 3.4% | 0.9% | 0.002 |
| Cardiac or Vascular Event | 41% | 20% | <.001 |
| Any CMV > 500 | 14% | 12% | 0.338 |
| SBP Mean (mm Hg mean ± SD) | 141 ± 13 | 142 ± 12 | 0.357 |
| Categorical SBP Mean | 0.172 | ||
| SBP Mean < 110 | 3% | 1% | 0.061 |
| SBP Mean = 110–159 | 92% | 93% | 0.455 |
| SBP Mean >=160 | 6% | 6% | 0.946 |
| Pulse Pressure SDev | 14.8 ± 3.7 | 13.8 ± 3.8 | <.001 |
| Pulse Mean | 81 ± 9 | 80 ± 9 | 0.095 |
| Glucose Mean (g/dL) | 140 ± 33 | 134 ± 32 | 0.002 |
| HGB Mean (g/dL) | 10.7 ± 1.6 | 11.3 ± 1.4 | <.001 |
| HGB Slope per30days (g/dL/30 days)† | −0.21 ± 3.72 | 0.33 ± 0.60 | 0.021 |
| Maximum eGFR (ml/min/1.73 m2) | 64 ± 41 | 69 ± 23 | 0.043 |
| eGFR SDev (ml/min/1.73 m2) | 11.0 ± 8.4 | 10.1 ± 5.3 | 0.073 |
| eGFR Slope perWK - Maximum Value (ml/min/1.73 m2/week) | −5.5 ± 22.1 | −1.4 ± 3.7 | 0.003 |
| Tacrolimus Mean (ng/ml) | 8.6 ± 1.6 | 8.8 ± 1.3 | 0.043 |
| Tacrolimus SDev (ng/ml) | 4.0 ± 1.4 | 3.7 ± 1.1 | <.001 |
| INP Readm Count | 1.6 ± 1.7 | 0.9 ± 1.3 | <.001 |
| ED Readm Count | .17 ± .74 | .15 ± .51 | 0.666 |
| EHR+NLP | |||
| BK plus Rejection | <.001 | ||
| Any BK > 500 and Rejection | 4% | 3% | 0.413 |
| Any BK > 500 Only | 11% | 14% | 0.124 |
| Rejection Only | 11% | 3% | <.001 |
| No BK > 500 and No Rejection | 74% | 79% | 0.057 |
†
HGB slope determined between 7 days post-transplant until the end of the exposure.
‡
Exposure period for 5-year model is 365 days.