Table 13.

Values of clinical chemistry parameters of male rat orally administered with the leaf extract of A. occidentale for 90 days. Values were as mean±SEM (N=15/group).

Blood Chemistry	Reference values	Vehicle	AO 20 mg/kgBW	AO 100 mg/kgBW	AO 500 mg/kgBW
BUN(mg/ dL)	10.7-20	19.91±0.70	18.68±0.79	17.95±0.78	19.37±1.02
Creatinine(ml/ dL)	0.3-0.5	0.50±0.02	0.50±0.03	0.47±0.02	0.45±0.02
Cholesterol(ml/ dL)	37-95	64.60±3.29	66.00±2.81	57.00±2.46	60.33±4.72
Triglyceride(ml/ dL)	27-160	75.92±8.24	48.86±7.79∗	46.40±3.29∗∗∗	46.20±4.27∗∗
ALT(U/L)	19-48	123.67±7.89	142.93±7.43	144.64±2.53	140.14±13.11
AST(U/L)	63-175	49.53±7.89	55.93±5.63	38.40±3.23	45.07±3.07
ALP(U/L)	36-131	66.33±5.14	82.60±7.64	54.07±4.49	62.50±5.27
Total Bilirubin(mg/ dL)	0.04-0.2	0.1±0.001	0.12±0.0145	0.1±0.00	0.1±0.00

Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP)

∗P value<.05, ∗∗P value<01, and∗∗∗P value<.001, compared to vehicle treated group.