Table 1.
Baseline patient characteristics.
| Parameter | All patients | <65 years | >65 years |
|---|---|---|---|
| Number | 218 | 125 | 93 |
| Sex (male/female) | 138/80 | 82/43 | 56/37 |
| Age median (range) (years) | 63 (18-89) | 52 (18-65) | 74 (66-89) |
| APACHE II score median (range) | 17 (2-43) | 15 (2-43) | 19 (5-40) |
| SAPS2 score median (range) | 43.0 (0-79) | 40 (9-79) | 45 (0-72) |
| ICU days median (range) | 7 (1-83) | 7 (1-70) | 7 (1-83) |
| Death during ICU or follow-up (%) | 47.2% | 36% | 51.6% |
| 28 d mortality | 24.8% | 18.2% | 31.3% |
| Ventilation time median (range) (h) | 129 (0.5-1363) | 127 (0.5-928) | 132 (1-1363) |
| Diabetes mellitus (%) | 30.7% | 20.0% | 45.16% |
| Body mass index (BMI) | 26.78 (16.6-86.5) | 26 (16.6-86.5) | 26.12 (19.3-61) |
| Creatinine | 1.3 (0-15) | 1.3 (0.2-15) | 1.35 (0-11.5) |
| Albumin | 27.0 (15.2- 52.2) | 26 (15.2-41) | 28.6 (15.8-52.2) |
| WBC median (range) (×103/μl) | 12.15 (0.1-67.4) | 11.65 (0.1-67.4) | 12.7 (0.1-66.2) |
| CRP median (range) (mg/dl) | 95.5 (<5-230) | 112 (5-230) | 90 (<5-230) |
| Procalcitonin median (range) (μg/l) | 0.7 (0-180.6) | 0.7 (0.06-125.2) | 0.65 (0-180.6) |
| Interleukin-6 median (range) (pg/ml) | 105 (0-83000) | 130 (2-28000) | 100 (0-83000) |
| Tumor necrosis factor median (pg/ml) | 19 (4.9-140) | 19 (4.9-140) | 20 (10-100) |
| Serum lactate (mmol/l) | 1.70 (0-21.9) | 1.5 (0-21.9) | 1.7 (0-20.8) |
| miR-155 median (range) (rel. ex.) | 9.35 (0.1-56.49) | 10.05 (0.17-56.49) | 8.63 (0.1-29.65) |
APACHE: acute physiology and chronic health evaluation; CRP: C-reactive protein; ICU: intensive care unit; SAPS: simplified acute physiology score; WBC: white blood cell count.