Table 2.

Functional and pathway enrichment analysis of target genes in degenerative disc AF cells.

Category	Term	Description	Count	P value
KEGG_PATHWAY	hsa04144	Endocytosis	5	0.0223
KEGG_PATHWAY	hsa05164	Influenza A	5	0.0752
KEGG_PATHWAY	hsa05134	Legionellosis	4	0.0045
KEGG_PATHWAY	hsa03013	RNA transport	4	0.0908
KEGG_PATHWAY	hsa04621	NOD-like receptor signaling pathway	3	0.0456
KEGG_PATHWAY	hsa00970	Aminoacyl-tRNA biosynthesis	3	0.0632
KEGG_PATHWAY	hsa00980	Metabolism of xenobiotics by cytochrome P450	3	0.0771
KEGG_PATHWAY	hsa04612	Antigen processing and presentation	3	0.0807
KEGG_PATHWAY	hsa05204	Chemical carcinogenesis	3	0.0882
KEGG_PATHWAY	hsa04350	TGF-beta signaling pathway	3	0.0958
KEGG_PATHWAY	hsa04933	AGE-RAGE signaling pathway	2	0.0801
REACTOME_PATHWAY	R-HAS-2022870	R-HAS-2022870	3	0.0051
REACTOME_PATHWAY	R-HAS-379716	R-HAS-379716	3	0.0073
REACTOME_PATHWAY	R-HAS-2129379	R-HAS-2129379	3	0.0177
REACTOME_PATHWAY	R-HAS-1442490	R-HAS-1442490	3	0.0466
REACTOME_PATHWAY	R-HAS-300178	R-HAS-300178	3	0.0618
GOTERM_CC_DIRECT	GO:0005737	Cytoplasm	45	0.0001
GOTERM_CC_DIRECT	GO:0070062	Extracellular exosome	37	5.6552E-08
GOTERM_CC_DIRECT	GO:0005634	Nucleus	37	0.0457
GOTERM_MF_DIRECT	GO:0005515	Protein binding	63	0.0005
GOTERM_MF_DIRECT	GO:0005524	ATP binding	14	0.0493
GOTERM_MF_DIRECT	GO:0044822	Poly(A) RNA binding	13	0.0152
GOTERM_MF_DIRECT	GO:009864	Cadherin binding involved in cell-cell adhesion	8	0.0009
GOTERM_MF_DIRECT	GO:0042803	Protein homodimerization activity	8	0.0904
GOTERM_MF_DIRECT	GO:0005201	Extracellular matrix structural constituent	4	0.0053
GOTERM_MF_DIRECT	GO:0051059	NF-kappaB binding	3	0.0109
GOTERM_BP_DIRECT	GO:0007165	Signal transduction	12	0.0457
GOTERM_BP_DIRECT	GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	10	0.0795
GOTERM_BP_DIRECT	GO:0098609	Cell-cell adhesion	9	0.0001

Note: BP, biological process; MF, molecular function; CC, cellular component; GO, gene ontology.