Table 2.

Central antinociceptive effect of Libidibia ferrea crude aqueous extract (CE), ethanolic extracts (CE20, CE40, CE60, and CE80), ethyl acetate (EAF), and aqueous (AqF) fractions at doses of 50, 100, and 200 mg/kg in the hot plate test in mice.

Administered treatment	Initial pain latency	Pain latency at the indicated time points after administration
	0 s	30 min	60 min	90 min	120 min
Control(saline)	13 + 5.0	6.2 + 6.8	4.8 + 3.3	7.8 + 5.1	6.3 + 2.1
Morfine (10 mg/kg)	8 + 2.3	27 + 3.0∗	23 + 7.8∗	25 + 6.4∗	26 + 2.6∗
CE 50 mg/kg	7.6 + 2.3	13.2 + 3.4	3.6 + 2.7	8.8 + 2.2	12 + 3.3
CE 100 mg/kg	6.6 + 2.1	8.8 + 2.2	8.0 + 2.0	22. 7 + 2.7∗	10, 4 + 2.9
CE 200 mg/kg	5.3 + 3.2	10.6 + 2.2	22. 0+ 3.2∗	23,1+ 2.7∗	6.6 + 4.1
CE20- 50 mg/kg	5.8 + 3.1	13.6 + 4.0	7.6 + 2.55	8.4 + 2.8	12. 2 + 3.2
CE20-100mg/kg	7.0 + 2,0	7.6 + 2.9	8.0 + 2.6	9.0 + 3.0	10 + 2.2
CE20-200mg/kg	8.0 + 3.2	10.8 + 2.8	8.2 + 3.4	10.4 + 2.7	7.4 + 4.1
CE40-50 mg/kg	5.9 + 2.0	8.4 + 3.2	7.6 + 2.9	9.2 + 3.1	11.8 + 3.5
CE40-100mg/kg	6.0 + 3.2	13,2 + 2.6	7.2 + 2.5	3.6 + 3.1	9.6 + 3.0
CE40-200mg/kg	7.6 + 1.9	17.4 + 2.9	17 + 2.8	12.8 + 2.1	16.8 + 2.8
CE60-50 mg/kg	5.9 + 2.3	5.6 +2.8	9.0 + 3.4	8.0 + 3.6	8.2 + 2.3
CE60-100mg/kg	6.2 + 2.2	8.8 + 4.0	9.0 + 3.4	7.2 + 2.4	9.4 + 2.6
CE60-200mg/kg	6.0 + 2.0	5.8 + 2.2	3.4 + 11.8	12.6 + 2.4	17.2 + 2.9
CE80-50 mg/kg	6.5 + 3.2	8.8 + 3.7	7.6 + 2.9	9.4 + 3.3	11. 4 + 2.8
CE80-100mg/kg	7.0 + 3.2	12.6 + 2.8	8.6 + 2.8	13.4 + 3.3	10.2 + 3.2
CE80-200mg/kg	6.0 + 3.2	16,8 + 3.3	7.2 + 2.4	16.2 + 3.0	14.8 + 3.2
EAF50 mg/kg	4.5 + 2.0	7.25 + 2.3	13.4 + 3.0	8.6 + 0.6	12.2 + 3.2
EAF100 mg/kg	4.5 + 2.0	9.0 + 4.0	8.4 + 3.2	9.8 + 2.7	10 + 2.2
EAF200 mg/kg	5.0 + 2.2.	6,0 + 2,7	4.8 + 3.7	10.4 + 2.7	6.2 + 3.9
AqF50 mg/kg	4.8 + 1.9	6.0 + 2.7	11.2 + 2.9	8.8 + 3.1	12.2 + 3.2
AqF100 mg/kg	5.0 + 2.0	8.8 + 3.6	9.0 + 3.4	9.8 + 2.7	10 + 2.2
AqF200 mg/kg	5.4 + 2.2	6.6 + 3.3	3.4 + 1.8	22.4 + 2.6∗	7.4 + 4.1