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. 2019 Feb 24;2019:8639618. doi: 10.1155/2019/8639618

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Copyright © 2019 Ji-Shi Ye et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effects of HNK on NLRP3 inflammasome activation in the hippocampus induced by surgery/sevoflurane. (a–c) The Western blot representative blots of NLRP3, ASC, and Caspase-1 (n = 6 per group). (d) The immunohistochemistry of NLRP3 in the hippocampus at 24 h after surgery/sevoflurane. (e–g) The concentration of IL-1β and IL-18 in the hippocampus at postoperative 1, 3, and 7 days. The data are presented as the mean ± standard error of the mean for each group. ^#p < 0.05 versus the control group; ^$p < 0.05 versus the surgery+vehicle group; and ^&p < 0.05 versus the surgery+HNK group.