TABLE 4.

Cox regression analysis of biomarker levels at the 6-week follow-up and associations to 5-year all-cause mortality in 267 hospitalised patients with community-acquired pneumonia

Biomarker	Univariate analysis		Multivariate analysis#
	HR (95% CI)	p-value	HR (95% CI)	p-value
WBCs	4.74 (1.89–11.87)	0.001	2.81 (1.06–7.44)	0.037
CRP	1.67 (1.34–2.08)	<0.001	1.29 (0.99–1.67)	0.055
PCT	2.82 (1.71–4.63)	0.001	1.73 (0.97–3.09)	0.063
Calprotectin	2.56 (1.62–4.04)	<0.001	2.18 (1.27–3.74)	0.005
PTX3	2.31 (1.49–3.59)	<0.001	1.26 (0.83–1.92)	0.282

HR: hazard ratio; WBC: white blood cell; CRP: C-reactive protein; PCT: procalcitonin; PTX3: pentraxin 3. ^#: adjusted for age, heart failure, active malignant disease, chronic obstructive pulmonary disease and renal disease.