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. 2019 Mar 7;7:e6560. doi: 10.7717/peerj.6560

Table 2. Gene ontology analysis of differentially expressed genes associated with LGG and HGG.

Expression Category Term Count % P-value FDR
Upregulated GOTERM_BP_FAT GO:0016477—cell migration 13 22.80702 3.95E-05 0.067618
GOTERM_BP_FAT GO:0050900—leukocyte migration 8 14.03509 5.28E-05 0.090452
GOTERM_BP_FAT GO:0040011—locomotion 14 24.5614 1.09E-04 0.185762
GOTERM_BP_FAT GO:0051674—localization of cell 13 22.80702 1.22E-04 0.208673
GOTERM_BP_FAT GO:0048870—cell motility 13 22.80702 1.22E-04 0.208673
GOTERM_MF_FAT GO:0019838—growth factor binding 4 7.017544 0.004366 5.428929
GOTERM_MF_FAT GO:0019834—phospholipase A2 inhibitor activity 2 3.508772 0.010298 12.37092
GOTERM_MF_FAT GO:0005102—receptor binding 10 17.54386 0.010815 12.95228
GOTERM_MF_FAT GO:0005201—extracellular matrix structural constituent 3 5.263158 0.018986 21.69308
GOTERM_MF_FAT GO:0005125—cytokine activity 4 7.017544 0.019477 22.19193
GOTERM_CC_FAT GO:0005615—extracellular space 16 28.07018 3.09E-06 0.003877
GOTERM_CC_FAT GO:0005578—proteinaceous extracellular matrix 7 12.2807 4.24E-04 0.531176
GOTERM_CC_FAT GO:0031012—extracellular matrix 8 14.03509 5.41E-04 0.676623
GOTERM_CC_FAT GO:0060205—cytoplasmic membrane-bounded vesicle lumen 4 7.017544 0.002985 3.680925
GOTERM_CC_FAT GO:0031983—vesicle lumen 4 7.017544 0.003066 3.779192
Downregulated GOTERM_BP_FAT GO:0007399—nervous system development 15 31.91489 3.29E-04 0.533895
GOTERM_BP_FAT GO:0007420—brain development 7 14.89362 0.00548 8.553316
GOTERM_BP_FAT GO:0060322—head development 7 14.89362 0.007003 10.80691
GOTERM_BP_FAT GO:0031344—regulation of cell projection organization 6 12.76596 0.011466 17.11031
GOTERM_BP_FAT GO:0007417—central nervous system development 7 14.89362 0.019918 27.91963
GOTERM_MF_FAT GO:0005509—calcium ion binding 6 12.76596 0.021579 24.70502
GOTERM_MF_FAT GO:0019911—structural constituent of myelin sheath 2 4.255319 0.02239 25.5132
GOTERM_MF_FAT GO:0032403—protein complex binding 5 10.6383 0.092825 71.83703
GOTERM_CC_FAT GO:0097458—neuron part 15 31.91489 6.61E-06 0.007993
GOTERM_CC_FAT GO:0045202—synapse 9 19.14894 8.96E-04 1.078808
GOTERM_CC_FAT GO:0043005—neuron projection 9 19.14894 0.00424 5.011629
GOTERM_CC_FAT GO:0033269—internode region of axon 2 4.255319 0.01097 12.49482
GOTERM_CC_FAT GO:0043209—myelin sheath 4 8.510638 0.01206 13.65505