Table 1.
Characteristics of the patients with neurological diseases who were transplanted intrathecally by their marrow stem cells, during 2011–2015
| Disease | n | Age (yrs) range (median) | Sex M:F | The duration of the disease (yrs) range (median) | Mononuclear cells range (median), | BM volume (mL) range (medium) | Post-treatment follow-up (yrs) range (median) | Clinical improvement, ratio (%) |
|---|---|---|---|---|---|---|---|---|
| Advanced Parkinson’s disease | 12 | 42–73 (64) | 6:6 | 2–14 (5) | 1.2–450 (3.0)×107 | 90–200 (100) | 3–6 (4) | 9/12 (75) |
| Complete paralysis | 6 | 23–53 (35) | 2:4 | 1/2–5 (2) | 2–29 (4.0)×107 , | 100–200 (100) | 3–6(3.5) | 0/6 |
| Incomplete paralysis | 4 | 35–40 (36) | 3:1 | 2–4 (3) | 2.4–16 (7.0)×107 | 100–200 (100) | 4–5.5 (4) | 0/4 (25) |
| Cerebral palsy | 28 | 2.5–30 (11) | 16:12 | 2.5–30 (11) | 2.0–19.0 (2.8)×107 | 50–160 (100) | 3.5–5.5 (3) | 20/28 (71) |
| Hypoxic brain damage | 7 | 6–28 (15) | 4:3 | 2–25 (5) | 1.4–8 (2.0)×107 | 100–120 (100) | 3.5–4 (3) | 5/7 (71) |
| Autism | 2 | 8,9 | 1:1 | 5, 8 | 0.7, 22.4×107 | 50, 100 | 5.5,5 | 0/2 (0) |
| Multiple sclerosis | 4 | 29–40 (36.5) | 2:2 | 6–18 (13) | 3–10 (6.4)×107 | 100–120 (100) | 3.5–5 (3.5) | 4/4 (100) Relapse 2/4(50) |
| Progressive cerebellar atrophy | 5 | 9–50 (34) | 4:1 | 3–25 (9) | 1.2–65 (2.6)×107 | 100–140 (100) | 3–6 (3.5) | 4/5 (80) |
| Hereditary spinocortico-cerebellar atrophy | 1 | 30 | F | 28 | 3.2×107, 120 | 5 | +ve | |
| Hereditary neuropathy | 1 | 54 | M | 8 | 8×107, 100 | 3.5 | +ve | |
| Friedreich’s ataxia | 1 | 23 | M | 7 | 1.6×107, 75 | 4 | -ve | |
| Amyotrophic lateral sclerosis | 1 | 56 | F | 12 | 2×107, 100 | 3.5 | -ve | |
| Primary lateral sclerosis | 1 | 61 | M | 4 | 4×107, 100 | 3.5 | -ve | |
| Kernicterus neuropathy | 2 | 7,30 | 1:1 | 7, 30 | 8.8, 6.4×107 | 100, 140 | 3, 4.5 | 2/2 (100) |
| Head injury (colpocephaly) | 1 | 34 | M | 9 | 14×107, 160 | 4 | +ve | |
| Head trauma | 1 | 21 | M | 4 | 4×107, 100 | 3.5 | -ve | |
| Cerebrovascular accident | 1 | 55 | M | 10 | 6.4×107, 90 | 4 | -ve | |
| Neurological sequel of meningitis | 1 | 39 | F | 8 | 3.8×107, 70 | 4 | +ve | |
| Transverse myelitis | 1 | 38 | M | 8 | 1.72×107, 160 | 3.5 | -ve | |
| Total | 80 | Mean MNCs=4.0×107 Mean CD34+ CD38– cells=1.4% Mean CD45– D146+ cells=0.0007% |
48/80 (60) |
n: Number, BM: Bone marrow, +ve: positive: some improvements, -ve: negative (no improvement), MNCs: mononuclear cells