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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Gastroenterology. 2018 Nov 13;156(4):1041–1051.e4. doi: 10.1053/j.gastro.2018.11.017

Figure 1. Effects of bile diversion to the ileum in HFD-fed, obese global Tgr5−/− and intestinal Fxr deficient (FxrΔ/E) mice.

Figure 1.

(A) Surgical schematic of bile diversion operations6. Mice underwent surgical bile diversion to the ileum (GB-IL) or no operation (Chow). Average body weight (B, E), interval body composition assessments (C, F), daily food intake (D, G), oral glucose excursions (H and J) and glucose area under the curve (AUC; I and K) in high-fat diet- (HFD-) fed obese Tgr5−/− and FxrΔ/E mice after bile diversion to the ileum (GB-IL). (Tgr5−/−: n=14 Con HFD, 5 GB-IL; FxrΔ/E n=5 Con HFD, 7 GB-IL). Data are represented as the mean ± SEM. Statistical analysis using Student’s t-test. ***P<0.001; ****P<0.0001.