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. Author manuscript; available in PMC: 2019 Mar 10.
Published in final edited form as: Gastroenterology. 2018 Nov 13;156(4):1156–1172.e6. doi: 10.1053/j.gastro.2018.11.019

Figure 1. NOX1 controls HCC development.

Figure 1.

(A) Representative livers from DEN-injected mice of indicated genotypes 9 month after birth (scale bar, 1 cm). (B) Liver weight:body weight (LW/BW) ratios, tumor numbers and maximum sizes of DEN-induced HCCs. Serum ALT was quantified by Infinity reagent (n≧7 mice per group). (C) Representative liver sections from DEN-injected mice that were stained with H&E, AFP or YAP (scale bar, 0.5 mm). (D) Percentage of positive staining areas of AFP and YAP (n≧7 mice per group). Data are shown as mean ± s.e.m. Student’s t-test for independent samples and unequal variances was used to assess statistical significance (*P<0.05, **P<0.01, ***P<0.001).