Table S4. Meta-regression results of different variables on all and high grades.
| Pneumonitis | Beta ± SE, P value | ||
|---|---|---|---|
| All studies | Only NSCLC | Among anti-PD-1 | |
| All grade pneumonitis | |||
| Age | 0.2798±0.2411, P=0.2459 | 0.4290±0.3231, P=0.1842 | 0.2663±0.2433, P=0.2738 |
| Female% | 0.0210±0.0348, P=0.5452 | −0.0663±0.0883, P=0.4526 | 0.0180±0.0354, P=0.6110 |
| PS ≥1 | −0.0380±0.0260, P=0.1440 | 0.0866±0.1266, P=0.4943 | −0.0378±0.0260, P=0.1459 |
| Smokers | 0.0954±0.0588, P=0.1043¶ | 0.0946±0.0651, P=0.1461¶ | 0.0952±0.0588, P=0.1051¶ |
| RTH | −0.0162±0.1463, P=0.9117 | −0.0162±0.1463, P=0.9117 | -0.0162±0.1463, P=0.9117 |
| High grade pneumonitis | |||
| Age | 0.4080±0.2269, P=0.0721¶ | 0.0415±0.3712, P=0.9110 | 0.3856±0.2286, P=0.0916¶ |
| Female% | 0.0254±0.0319, P=0.4265 | 0.0351±0.0970, P=0.7177 | 0.0194±0.0329, P=0.5565 |
| PS ≥1 | −0.0239±0.0448, P=0.5937 | −0.0148±0.1421, P=0.9173 | −0.0229±0.0448, P=0.6087 |
| Smokers | 0.0051±0.0701, P=0.9416 | −0.0023±0.0753, P=0.9762 | 0.0080±0.0702, P=0.9095 |
| RTH | −0.0727±0.1545, P=0.6381 | −0.0727±0.1545, P=0.6381 | −0.0727±0.1545, P=0.6381 |
*, positive beta reflects an increase in pneumonitis with increase in the variable, while negative beta reflects a decrease in pneumonitis with increase in the variable; ¶, those in italic show trends toward statistical significance. NSCLC, non-small cell lung cancer; PS, performance status; RTH, radiotherapy; SE, slandered error.