Table 3. Haplotype analysis of four tagSNPs of TLR1 in the comparison of LTBI vs. TB.
| Haplotype | TB (freq) | LTBI (freq) | Chi2 | Pearson’s P | Odds ratio (95% CI) | P* |
|---|---|---|---|---|---|---|
| rs4833095-rs5743604 | ||||||
| CA | 32.00 (0.077) | 25.00 (0.062) | 0.623 | 0.429922 | 1.244 (0.723–2.139) | 1 |
| CG | 199.00 (0.476) | 223.00 (0.557) | 5.426 | 0.019877 | 0.721 (0.548–0.950) | 0.191 |
| TA | 187.00 (0.447) | 152.00 (0.380) | 3.823 | 0.050583 | 1.321 (0.999–1.746) | 0.396 |
| Global result | 400 | 418 | 5.445 | 0.066 | ||
| rs5743557-rs5743596 | ||||||
| AA | 123.00 (0.294) | 134.87 (0.337) | 1.819 | 0.177447 | 0.816 (0.607–1.097) | 0.874 |
| AG | 41.00 (0.098) | 47.13 (0.118) | 0.854 | 0.355397 | 0.812 (0.521–1.264) | 1 |
| GG | 254.00 (0.608) | 216.87 (0.542) | 3.418 | 0.064502 | 1.300 (0.984–1.717) | 0.475 |
| Global result | 400 | 418 | 3.454 | 0.178 |
*, P value after 1,000-fold permutation testing using the Haploview software. LTBI, latent tuberculosis infection; TB, tuberculosis; OR, odds ratio; CI, confidence interval.