Table S3. Gene-gene interactions between TLR1, TLR6, MYD88 and TIRAP using MDR analysis.

Group	Best model	Testing accuracy	CV consistency	P value*
HC vs. LTBI	rs4833095	0.5314	10/10	0.210–0.211
LTBI vs. TB	rs5743604, rs1039559, rs7744	0.5348	7/10	0.428–0.429

*, P value of each best model was calculated after a 1,000-fold permutation test, applying testing accuracy and CV consistency in the MDR permutation test module. P<0.05 was significant. Testing accuracy: the ratio of correct classifications to the total classifications in the testing set; CV consistency (cross validation consistency): the number of times a combination model was selected as the best model in a 10-fold cross validation. HC, uninfected healthy controls; LTBI, latent tuberculosis infection; TB, tuberculosis.