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. 2019 Mar 4;9:42. doi: 10.3389/fcimb.2019.00042

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Copyright © 2019 Eisenreich, Rudel, Heesemann and Goebel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intracellular bacterial pathogens (IBPs) influence the activity of central metabolic regulators of their host cells. Bacterial factors activate components of the PI3K/Akt/mTOR cascade and Myc, or alter the concentration and/or activity of p53 and HIF-1 (see text and Table 3 for details). Most of these interactions lead to enhanced glucose uptake, increased aerobic glycolysis and enhanced PPP activity as well as to activation of anabolic pathways in the infected host cells. Activation of Myc by some IBPs also enhances Gln uptake and glutaminolysis. Lm, Listeria monocytogenes; Sf, Shigella flexneri; St, Salmonella enterica; Lp, Legionella pneumophila; Mt, Mycobacterium tuberculosis; Ba, Brucella abortus; Bh, Bartonella henselae; Cb, Coxiella burnettii; Ct, Chlamydia trachomatis; Ft, Francisella tularensis. For other abbreviations, see Figures 1, 2.

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