Table 2.
RNA-viruses: Interactions of viral factors and host cell targets that that have been shown or are expected to cause metabolic reprogramming of the virus-infected cells.
| RNA viruses | Interacting viral components | Cellular targets | Used host cells and references |
|---|---|---|---|
| IAV | Unknown | Glycolysis (+) | MDCK epithelial cell line (Ritter et al., 2010) |
| Myc (GLS) (+) | Primary human bronchial epithelial cells (NHBE) | ||
| Unknown | (Thai et al., 2015) | ||
| Myc (+) | (Smallwood et al., 2017) | ||
| PI3K/Akt (+) | |||
| mTOR (+) | |||
| RSV | Unknown | HIF-1 (+) | Primary human bronchial epithelial cells (HBEpC) (Kilani et al., 2004) |
| HCV | Unknown | AMPK (–) | Huh-7 cells (Mankouri et al., 2010) |
| mTOR (+) | Immortalized human hepatocytes (IHH) and Huh7.5 cell line (Bose et al., 2012) |
||
| HIF-1 (+) | UHCVcon-57.3, UCp7con-9.10, and UNS3-5Bcon-27 cell lines (Ripoli et al., 2010) |
||
| NS5 | HK-2 (+) | Huh-7.5 cell line (Diamond et al., 2010) |
|
| Huh7.5, HepG2, and HEK 293T cell lines (Ramiere et al., 2014) |
|||
| NS3, NS5 | RB and p53 (–) | (Lemon and McGivern, 2012) | |
| Huh-7.5 cell line | |||
| PDK (+) | (Jung et al., 2016) | ||
| HEV | ORF3 | PI3K/Akt (+) HIF-1 (+) |
Huh7, ORF3/4nd pCN cell lines (Moin et al., 2009) |
| DENV | NS4A | Autophagy Lipid metabolism (+) |
MDCK cells (McLean et al., 2011) |
| Huh-7.5, Huh-7, HepG2 cell lines, and baby hamster kidney cell line BHK-21 (Heaton and Randall, 2010) |
|||
| NS3A | FASN (+) | Huh-7.5, HEL, HEK 293T, BHK-21, and Vero cells (Heaton et al., 2010) |
|
| Unknown | Glycolysis (+) | Primary HFFs and TIME cells (Fontaine et al., 2015) |
|
| NS1 | GAPDH (+) | BHK-21 cells and human umbilical vein endothelial cells (HUVEC-C) (Allonso et al., 2015) |
|
| HIV-1 | Unknown | GLUT-1 (+) | Human CD4+ T-cells (Palmer et al., 2016) |
| Vpr | HIF-1 (+) | U937 MP cell line (Deshmane et al., 2009; Barrero et al., 2013) |
|
| Vpr | Dysregulation of glutamate metabolism | U937 (Datta et al., 2016) |
|
| Increase in glucose uptake and glycolysis in CD4 T cells, but decrease in U937 MPs | CD4 T-cells and U937 MP cell line (Hollenbaugh et al., 2011) |
||
| Env | mTOR (+) | Human MOs, CD4+ T lymphocytes, myeloid DCs (MyDCs), Hut-CCR5, HEK 293T, and HeLa P4-R5 cell lines (Blanchet et al., 2010) |
|
| HTLV | Tax | PI3K/Akt (+) | T-cell leukemia cell lines MOLT-4 and CCRF-CEM, HTLV-1-infectd T-cell lines MT-2, MT-4, SLB-1 and HUT-102 (Tomita et al., 2007) |
The host cells used in the studies are also indicated. DENV, dengue virus; HCV, HEV, hepatitis C and E viruses; HIV, human immunodeficiency virus; HTLV, human T-lymphotropic virus; IAV, influenza A virus; RSV, respiratory syncytial virus.