Table 3.
Intracellular bacterial pathogens: Interactions of bacterial factors and host cell targets expected to cause metabolic reprogramming of the IBP-infected cells.
| Intracellular bacterial pathogen (IBP) | Interacting bacterial component | Host cell target | Used host cells and references |
|---|---|---|---|
| VACUOLAR IBPs | |||
| Salmonella typhimurium | SopB | PI3K/Akt/mTOR (+) | HeLa cells (Cooper et al., 2011) |
| SopB | Class II PI3-kinases activate Akt | HeLa and mouse embryonic fibroblast cells (MEFs) (Roppenser et al., 2013) |
|
| SP-2 effector(s) | FAK/Akt/mTOR (+) | Peritoneal MPs (PEMs) (Owen et al., 2014) |
|
| Salmochelin | HIF-1 (+) | HeLa cells, HMEC (Hartmann et al., 2008) |
|
| Unknown | p53 (+) | HCT116, IEC-18 cells, and MEFs (Wu et al., 2010) |
|
| Legionella pneumophila | Dot/Icm effector protein(s) | PI3K/Akt/mTOR (+) | Mouse BMMs (Abshire et al., 2016) |
| Lgt effector family | mTORC1 (+) | (Escoll and Buchrieser, 2018) | |
| SidE effector family | mTORC1 (–) | (De Leon et al., 2017) | |
| Mycobacterium tuberculosis | Unknown | PI3K/Akt/mTOR (+) | PBMCs (Lachmandas et al., 2016) |
| Unknown | HIF-1 (+) | C57BL/6 mice (Shi et al., 2015) |
|
| Unknown | p53 (+) | Blood human MOs (Galietti et al., 2001) |
|
| Brucella abortus | Unknown | Warburg shift | THP-1 cells (Czyz et al., 2017) |
| Chlamydia trachomatis | Unknown | PDPK1, Myc, HK-2 (+) | HeLa cells, fallopian tube primary epithelial organoids (Al-Zeer et al., 2017) |
| Unknown | HIF-1 (+) | HeLa cells (Sharma et al., 2011) |
|
| Unknown | p53 (–) | HUVEC cells (Siegl et al., 2014) |
|
| Coxiella burnetii | Unknown | Akt (+) | Primary human alveolar MPs (Hussain and Voth, 2012) |
| CYTOSOLIC IBPs | |||
| Shigella flexneri | OspB | mTOR (+) | HeLa, mouse embryonic fibroblasts (MEFs) (Lu et al., 2015) |
| Unknown | Akt (+) | HeLa cells | |
| mTOR (–) | (Tattoli et al., 2012) | ||
| Listeria monocytogenes | InlB | PI3K/Akt (+) | LS174T and Jar cell lines (Gessain et al., 2015) |
| InlB | Met-dependent phosphorylation of mTOR (+) | HeLa cells (Bhalla et al., 2017) |
|
| Francisella tularensis | Unknown | PI3K (+), mTOR (+) | Peritoneal MPs from C57BL/6 mice (Edwards et al., 2013) |
| Capsule | HIF-1 (–) | BMDM of C57BL/6 mice (Wyatt et al., 2016) |
|
The host cells used in the studies are also indicated.