Table 3.

Associations between ANU-ADRI scores and DMN sub-region volumes assessed by multiple linear regression analyses and controlling for age, sex, ICV and APO*E4 genotype. Significance levels are reported after Bonferoni corrections

ROI
	MOF		ECC		P-HC		FUS		PCC		ICC		IPL		PCU
	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right	Left	Right
ANU-ADRI	− 15.64	− 8.45	− 3.54	− 2.78	− 6.31	− 6.50	− 43.71	− 42.78	− 4.23	− 7.41	− 7.31	− 7.70	− 29.39	− 50.92	− 27.2	− 30.64
	p = 0.002	p = 0.056	p = 0.199	p = 0.315	p = 0.011	p = 0.008	p < 0.001	p < 0.001	p = 0.244	p = 0.051	p = 0.019	p = 0.014	p = 0.012	p < 0.001	p = 0.001	p < 0.001
Sex	− 300.06	− 319.24	− 159.67	− 114.15	− 30.49	15.89	− 474.23	− 515.79	− 238.59	− 184.72	− 154.29	− 83.16	− 607.96	− 841.46	− 182.48	− 412.92
	p < 0.001	p < 0.001	p < 0.001	p = 0.002	p = 0.348	p = 0.627	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p = 0.047	p < 0.001	p < 0.001	p = 0.083	p < 0.001
Age	− 26.25	− 26.88	5.45	4.46	− 17.18	− 12.22	− 56.10	− 22.17	− 12.57	− 33.43	− 30.08*	− 17.37	− 105.59	− 198.84	− 87.06	− 84.45
	p = 0.179	p = 0.117	p = 0.608	p = 0.677	p = 0.073	p = 0.205	p = 0.154	p = 0.548	p = 0.367	p = 0.024	p = 0.013	p = 0.154	p = 0.021	p < 0.001	p = 0.005	p = 0.011
ICV	0.002	0.001	0.0005	0.0004	0.001	0.001	0.002	0.003	0.001	0.001	0.001	0.001	0.004	0.004	0.003	0.003
	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001	p < 0.001
APO*E4	167.87	0.131	13.69	20.57	12.94	− 10.20	98.56	192.16	12.86	− 73.02	− 42.10	16.62	− 33.40	80.43	− 19.61	150.75
	p = 0.009	p = 0.999	p = 0.693	p = 0.555	p = 0.677	p = 0.744	p = 0.441	p = 0.111	p = 0.777	p = 0.128	p = 0.282	p = 0.674	p = 0.821	p = 0.638	p = 0.845	p = 0.157
Constant	4,163.24	4,882.05	977.08	911.54	2,270.26	1,668.88	9,214.95	5,666.56	2,663.05	3,901.43	3,094.82	2,493.38	12,198.5	18,692.60	9,034.41	9,670.33
	p = 0.002	p < 0.001	p = 0.156	p = 0.188	p < 0.001	p = 0.008	p < 0.001	p = 0.018	p = 0.004	p < 0.001	p < 0.001	p = 0.002	p < 0.001	p < 0.001	p < 0.001	p < 0.001
Adj. R2	0.339	0.293	0.178	0.118	0.170	0.181	0.236	0.333	0.222	0.205	0.267	0.132	0.299	0.364	0.331	0.327
Res. Std. error	599.24	527.03	327.72	327.65	293.33	294.23	1,210.10	1,136.56	427.81	453.39	369.18	374.05	1,395.24	1,614.73	947.24	1,007.58
F statistic	47.888***	38.924***	20.860***	13.213***	19.813***	21.113***	29.415***	46.772***	26.987***	24.705***	34.304***	14.915***	40.069***	53.474***	46.277***	45.536***
N	459	458	460	457	459	457	461	459	457	460	458	459	459	459	458	460

Significance: *p < 0.05, **p < 0.01, ***p < 0.001