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. 2019 Mar 4;10:120. doi: 10.3389/fgene.2019.00120

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Copyright © 2019 Liu, Lu, Li and Zuo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Oct4 combination intensity and time on gene expression at different stages of cell development for all genes from GEO. X-axis represents different stages of cell development after 0, 1, 3, 5, 7, 11, 15, and 18 days. Y axis represents parameter value. Curve in red, green, blue, and black represents values of parameter β₁, β₂, β₃ and ε of the proposed generalized linear regression model, respectively.