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. 2019 Mar 4;10:257. doi: 10.3389/fimmu.2019.00257

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Copyright © 2019 Rudolph, McArthur, Magder, Barnes, Chen and Sztein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in Activated CD8+ CD69+ T cell Populations Following Ty21a Vaccination. (A) Scatter plot showing the percentages of CD69+ CD8+ T cells among pre- and post-Ty21a unstimulated PBMC (media). Bars represent medians with whiskers indicating interquartile ranges. (B) Connected dot plots showing each participants' pre- and post-Ty21a CD8+ CD69+ expression levels following co-culture with S. Typhi-infected HLA-E restricted antigen presenting target cells. Data divided among 6–15 year-old pediatric (n = 10), 16–17 year-old pediatric (n = 8), and adult (n = 13) participants. (C) Bars representing the proportion of CD8+ CD69+ responders over baseline levels (cut-off of 0.1%) following co-culture with S. Typhi-infected HLA-E restricted antigen presenting target cells. Statistics were analyzed by unpaired t-test. (*p < 0.05).