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. 2018 Dec 19;4(3):470–483. doi: 10.1016/j.ekir.2018.12.006

Figure 3.

Figure 3

Systemic iron homeostasis in wild-type (WT) and interleukin-6 deficient (Il6KO) juvenile mice with and without chronic kidney disease (CKD). (a) Serum hepcidin. (b) Serum iron. (c) Spleen tissue iron concentration. No statistically significant differences in spleen iron content were observed between Il6KO CKD(−) and Il6KO CKD(+) mice. (d) Representative images of spleen and bone marrow iron stains (Prussian blue); original magnification ×40. WT CKD(+) mice had more blue-stained ferric iron deposits in the spleen and bone marrow than their WT CKD(−) controls, whereas less iron was deposited in the spleen and bone marrow of Il6KO CKD(+) mice compared with WT CKD(+) mice. Increase in bone marrow adiposity was seen in both WT CKD(+) and Il6KO CKD(+) mice. Error bars are SDs. *P < 0.05; **P < 0.01. n ≥ 5 per group. Scale bars = 50 μm.