Table 1.
Parameters of chronic kidney disease in wild-type mice
| Parameters | Control diet (n = 8) | Adenine diet (n = 8) | P |
|---|---|---|---|
| BUN (mg/dl) | 32.5 ± 1.4 | 261.3 ± 10.0 | <0.001 |
| Serum creatinine (mg/dl) | 0.18 ± 0.02 | 1.17 ± 0.06 | <0.001 |
| Creatinine / BMI (cm2/dl) | 9.58 ± 1.21 | 105.70 ± 9.76 | <0.001 |
| Body length (cm) | 17.83 ± 0.12 | 15.49 ± 0.14 | <0.001 |
| Body weight (g) | 24.70 ± 0.51 | 10.93 ± 0.54 | <0.001 |
| BMI (kg/cm2) | 19.42 ± 0.32 | 11.36 ± 0.42 | <0.001 |
| IL-6 (pg/ml) | 6.8 ± 6.5 | 86.4 ± 21.3 | <0.001 |
| TNF-α (pg/ml) | 8.0 ± 4.5 | 33.8 ± 6.2 | <0.001 |
| WBC (103/μl) | 8.91 ± 0.93 | 3.12 ± 0.53 | 0.001 |
| Neutrophil (103/μl) | 0.78 ± 0.09 | 0.89 ± 0.17 | 0.56 |
| Neutrophil % | 9.28 ± 1.32 | 28.90 ± 2.48 | <0.001 |
| Monocyte (103/μl) | 0.07 ± 0.02 | 0.08 ± 0.02 | 0.82 |
| Monocyte % | 0.78 ± 0.14 | 2.27 ± 0.52 | 0.010 |
| Lymphocyte (103/μl) | 0.79 ± 0.83 | 2.04 ± 0.37 | <0.001 |
| Lymphocyte % | 87.12 ± 1.51 | 64.76 ± 3.27 | <0.001 |
| Platelets (103/μl) | 809.1 ± 55.5 | 1871.0 ± 190.4 | <0.001 |
| RBC (106/μl) | 10.27 ± 0.19 | 5.52 ± 0.26 | <0.001 |
| Hemoglobin (g/dl) | 14.73 ± 0.32 | 6.31 ± 0.39 | <0.001 |
| Hematocrit (%) | 52.22 ± 0.91 | 22.63 ± 1.31 | <0.001 |
| MCV (fl) | 50.86 ± 0.64 | 40.94 ± 0.51 | <0.001 |
| MCH (pg) | 14.73 ± 0.07 | 13.13 ± 0.16 | <0.001 |
| MCHC (g/dl) | 28.70 ± 0.26 | 32.30 ± 0.47 | <0.001 |
| Reticulocyte (103/μl) | 385.50 ± 32.82 | 391.70 ± 55.54 | 0.92 |
| Reticulocyte % | 3.73 ± 0.29 | 6.98 ± 1.02 | 0.003 |
| Hepcidin (ng/ml) | 669.0 ± 102.6 | 3016.0 ± 739.0 | 0.039 |
| Iron (μg/dl) | 131.6 ± 11.7 | 48.7 ± 16.2 | 0.029 |
| Spleen iron (μg/g) | 143.7 ± 40.2 | 302.9 ± 68.6 | 0.026 |
BMI, body mass index; BUN, blood urea nitrogen; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; RBC, red blood cells; WBC, white blood cells.