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. 2019 Feb 22;11(2):96. doi: 10.3390/pharmaceutics11020096

Table 3.

Presented here are some of the applications of ILs synergistically used to enhance drug delivery with chemical permeation enhancers (CPEs). APIs—active pharmaceutical ingredients.

Chemical Enhancer ILs Synergism Documented Reference
Lipid vesicles ILs based on methylimidazolium chloride
  • 1)

    Enhanced permeation

  • 2)

    Improved therapeutic range

  • 3)

    Vesicle stabilized

 [97]
Surfactants Dimethyl-imidazolium dimethyl-phosphate
  • 1)

    Enhanced permeation of sparingly soluble APIs

  • 2)

    Reduced cytotoxicity

 [98]
Terpenes Menthoxymethyl-3-methylimidazolium chloride
  • 1)

    Enhanced spatial drug delivery

  • 2)

    Improved targeting of specified receptors

 [99]
Amines Amine-based ILs
  • 1)

    Permeation of hydrophobic and hydrophilic molecules

  • 2)

    No skin tissue injury during permeation

 [81]
Alcohols N-tert-Alcohol-substituted imidazole
  • 1)

    Medium for selective reactions

  • 2)

    Lowered instances of unwanted byproducts

 [100]