Table 3.
Overview of families and subtypes of toxin genes in the venom-gland transcriptome of Malaysian Naja sumatrana (NS-M).
| Protein Family/Protein Subtype | Accession/Species | Transcript Abundance % a |
|---|---|---|
| Three-finger toxin (3FTx) | 91.11 (10) | |
| S-3FTx | 73.14 (5) | |
| Cytotoxin 2a | Q9PST4 (N. sputatrix) | 72.83 (1) b |
| Neurotoxin homolog NL1 | Q9DEQ3 (N. atra) | 0.21 (1) b |
| Cardiotoxin 7 | Q91996 (N. atra) | 0.10 (2) |
| Muscarinic toxin-like protein 1 | P82462 (N. kaouthia) | 0.00 (1) |
| L-3FTx | 8.23 (4) | |
| Long neurotoxin 7 | O42257 (N. sputatrix) | 4.91 (1) b |
| Alpha-neurotoxin NTX-4 | O57327 (N. sputatrix) | 3.30 (1) b |
| Long neurotoxin-like OH-31 | Q53B55 (O. hannah) | 0.01 (2) |
| UC-3FTx | 9.74 (1) | |
| Weak neurotoxin 5 | O42255 (N. sputatrix) | 9.74 (1) |
| Phospholipase A2 (PLA2) | 7.42 (2) | |
| Acidic phospholipase A2 C | Q92086 (N. sputatrix) | 7.39 (1) b |
| Phospholipase A2 GL16-1 | Q8JFB2 (L. semifasciata) | 0.03 (1) |
| Cysteine-rich secretory protein (CRISP) | 0.33 (4) | |
| Cysteine-rich venom protein natrin-1 | Q7T1K6 (N. atra) | 0.32 (1) b |
| Cysteine-rich venom protein natrin-2 | Q7ZZN8 (N. atra) | 0.01 (2) |
| Cysteine-rich venom protein kaouthin-2 | P84808 (N. kaouthia) | 0.01 (1) |
| Nerve growth factor (NGF) | 0.31 (2) | |
| Venom nerve growth factor 2 | Q5YF89 (N. sputatrix) | 0.31 (1) b |
| Venom nerve growth factor 1 | Q5YF90 (N. sputatrix) | 0.00 (1) |
| Vespryn (VES) | 0.25 (1) | |
| Thaicobrin | P83234 (O. hannah) | 0.25 (1) b |
| Snake venom C-type/lectin-like protein (Snaclec) | 0.22 (2) | |
| C-type lectin BfL-1 | Q90WI8 (B. fasciatus) | 0.22 (1) b |
| C-type lectin BfL-2 | Q90WI7 (B. fasciatus) | 0.00 (1) |
| Snake venom metalloproteinase (SVMP) | 0.17 (10) | |
| Snake venom metalloproteinase-disintegrin-like morcarhagin | Q10749 (N. mossambica) | 0.03 (1) |
| Zinc metalloproteinase-disintegrin-like cobrin | Q9PVK7 (N. kaouthia) | 0.07 (3) |
| Carinatease-1 | B5KFV1 (Tr. carinatus) | 0.02 (1) |
| Zinc metalloproteinase-disintegrin-like atrase B | D6PXE8 (N. atra) | 0.03 (3) b |
| Zinc metalloproteinase-disintegrin-like kaouthiagin-like | D3TTC1 (N. atra) | 0.01 (1) b |
| Zinc metalloproteinase-disintegrin-like atrase A | D5LMJ3 (N. atra) | 0.01 (1) |
| 5’ nucleotidase (5’ NUC) | 0.05 (2) | |
| Ecto-5’-nucleotidase 1 | U3FYP9 (M. fulvius) | 0.05 (1) b |
| 5’ nucleotidase | A0A024AXW5 (M. ikaheca) | 0.00 (1) |
| Natriuretic peptide (NP) | 0.05 (2) | |
| Natriuretic peptide Na-NP | D9IX97 (N. atra) | 0.05 (2) |
| L-amino acid oxidase (LAAO) | 0.02 (1) | |
| L-amino-acid oxidase | A8QL58 (N. atra) | 0.02 (1) b |
| Cobra venom factor (CVF) | 0.02 (3) | |
| Cobra venom factor | Q91132 (N. kaouthia) | 0.02 (3) b |
| Kunitz-type serine protease inhibitor (KSPI) | 0.01 (2) | |
| Putative Kunitz-type serine protease inhibitor | B2BS84 (A. labialis) | 0.01 (1) b |
| Kunitz-type protease inhibitor | U3FZD6 (M. fulvius) | 0.00 (1) b |
| Aminopeptidase (AP) | 0.01 (1) | |
| Aminopeptidase | U3FZS8 (M. fulvius) | 0.01 (1) b |
| Phospholipase B (PLB) | 0.01 (1) | |
| Phospholipase-B 81 | F8J2D3 (D. coronoides) | 0.01 (1) b |
| Cystatin | 0.01 (5) | |
| Cystatin | V8NX38 (O. hannah) | 0.00 (1) |
| Cystatin | A0A098LYB6 (O. aestivus) | 0.00 (4) |
| Vascular endothelial growth factor (VEGF) | 0.01 (2) | |
| Vascular endothelial growth factor 2 | U3FAK1 (M. fulvius) | 0.01 (1) b |
| Vascular endothelial growth factor A | A0A098LYD7 (O. aestivus) | 0.00 (1) |
| Dipeptidylpeptidase IV (DPP IV) | 0.00 (1) | |
| Dipeptidyl peptidase 4 | V8P9G9 (O. hannah) | 0.00 (1) b |
| Neprilysin | 0.00 (1) | |
| Neprilysin | A0A0B8RU83 (B. irregularis) | 0.00 (1) b |
| Hyaluronidase (HY) | 0.00 (4) | |
| Hyaluronidase | A0A194APD1 (M. tener) | 0.00 (4) b |
| Phosphodiesterase (PDE) | 0.00 (2) | |
| Snake venom phosphodiesterase | A0A2D0TC04 (N. atra) | 0.00 (2) b |
| Snake venom serine protease (SVSP) | 0.00 (2) | |
| Serine protease HTRA1 | A0A0B8RTL3 (B. irregularis) | 0.00 (1) b |
| Serine protease 23 | V8N8N4 (O. hannah) | 0.00 (1) b |
A., Agkistrodon/Austrelaps; B., Boiga/Bothrops/Bungarus; C., Crotalus; D., Drydalia; E., Elaphe; L., Laticauda; M., Micrurus/Micropechis; N., Naja; O., Opheodrys/Ophiophagus; T., Trimeresurus; and Tr., Tropidechis. a Transcript expression in percentage (%) based on FPKM (fragments per kilobase of exon model per million mapped reads). Number in bracket refers to the number of non-redundant transcripts in the toxin family. b Full-length transcript with more than 90% length coverage of the annotated sequence.