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. 2019 Jan 28;11(2):109. doi: 10.3390/v11020109

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Protein transduction domain (PTD)-fused Mx1-9R improved the survival of influenza PR8-infected mice. Mx1-9R was intranasally administered to mice one day prior to the day of infection. Mice were infected by intranasal application of 25 PFU of PR8 virus. (A) Body weight loss and survival were measured according to the Kaplan–Meier method (n = 4–5). (B) Viral titers in BAL fluid were measured by plaque assay (n = 4–5). (C) Intracellular IFN-γ staining and (D) NP_366–374 antigen-specific CD8 T-cell staining were performed to analyze the T-cell responses at 8 days post-infection (n = 4–6). Data are presented as the mean ± SEM.

Protein transduction domain (PTD)-fused Mx1-9R improved the survival of influenza PR8-infected mice. Mx1-9R was intranasally administered to mice one day prior to the day of infection. Mice were infected by intranasal application of 25 PFU of PR8 virus. (A) Body weight loss and survival were measured according to the Kaplan–Meier method (n = 4–5). (B) Viral titers in BAL fluid were measured by plaque assay (n = 4–5). (C) Intracellular IFN-γ staining and (D) NP_366–374 antigen-specific CD8 T-cell staining were performed to analyze the T-cell responses at 8 days post-infection (n = 4–6). Data are presented as the mean ± SEM.