Figure 4.

Kaplan–Meier survival curves of hamsters after Clostridium difficile infection (CDI) induction and successive treatment. Six groups of 10 hamsters were infected with ~10² C. difficile spores 24 h post clindamycin administration. Treatment started at 3 h prior to infection and was performed 3 h after infections and henceforth at 8 h intervals for 75 h before termination. Treatment was as indicated with vehicle (buffer only), vancomycin, control-WPI, WPI 100, WPI 1000 and WPI 10,000. WPI 10,000 survival curve was significantly (log-rank) different from control WPI (p < 0.0001), vancomycin (p < 0.0001) and vehicle (p < 0.00001). WPI 100 survival curve differed significantly (log-rank) from control WPI (p < 0.01), vancomycin p < 0.01) and vehicle (p < 0.001).