Table 1.
Characterization of poly(lactic-co-glycolic acid) (PLGA) nanoparticles obtained by using nanoprecipitation (NANOP) methods (experimental results are expressed as the mean ± SD, n = 6 for DLS measurements and n = 3 for encapsulation efficiency (EE)).
| Method | Zeta Potential (mV) | Size (nm) | Polydispersity | Encapsulation Efficiency (% LEV) |
|---|---|---|---|---|
| NANOP (PVA, AC) |
−4.3 ± 0.2 | 430 ± 20 | 0.61 ± 0.06 | 16 ± 1 |
| NANOP (Pluronic, AC) |
−7.4 ± 0.4 | 1000 ± 300 | 0.70 ± 0.09 | 27 ± 3 |
| NANOP (Pluronic, AC, HCl) |
−52 ± 3 | 222 ± 15 | 0.42 ± 0.05 | 27 ± 2 |
| NANOP (Pluronic, AC, pH = 4) |
−44 ± 3 | 950 ± 80 | 0.91 ± 0.09 | 21 ± 3 |
AC: Acetone.