Table 2.
Niosome-based non-viral vehicles designed to delivery genetic material inside cells.
| Cationic Lipid | Niosome Preparation | Cargo | Therapy | Testing Conditions | References |
|---|---|---|---|---|---|
| Polyamine derivatives | Thin-film | pEGFP-C2 | - | In vitro | [68,71] |
| Polyamine derivative | Thin-film | pOVA | Skin vaccination | In vivo | [72] |
| DODAB | Thin-film | pMEL34 and pLuc | Topical delivery | In vitro | [74,75] |
| DOTMA | Reverse-phase evaporation | pCMS-EGFP | Ocular delivery | In vitro and In vivo | [78] |
| 13 | Oil-in-water emulsion | pCMS-EGFP | - | In vitro | [30] |
| Glycerol-based amino lipid derivatives | Oil-in-water emulsion | pCMS-EGFP | Ocular delivery | In vitro and In vivo | [82] |
| DTPA | Emulsification-evaporation | pCMS-EGFP | Ocular delivery | In vitro and In vivo | [34] |
| DTPA | Reverse-phase evaporation | pUNO1-hBMP-7 | Bone regeneration | In vitro | [83] |
| Serinol-based amino lipid derivatives | Oil-in-water emulsion | pCMS-EGFP | - | In vitro | [46] |
| DC-Chol | Reverse-phase evaporation and thin-film | ASO | - | In vitro | [90,91] |
| DTPA | Thin-film | ASO | - | In vitro | [92] |
| PEGNIO | Thin-film | MUC1 Aptamer | Chemotherapy | In vitro | [102] |
| DTPA | Thin-film | AS1411 | Chemotherapy | In vitro | [105] |
| DOTAP | Ethanol injection | siLuc | - | In vitro | [108] |
| DDAB | Microfluidic | siRNA GFP | Chemotherapy | In vitro and In vivo | [110,111] |
| DOTAP | Ethanol injection | 2 siRNAs | Chemotherapy | In vivo | [112] |
| Gold niosomes (Nio-Au) | Ethanol evaporation | siRNA | Chemotherapy | In vivo | [113] |
| DOTAP | Thin-film | siRNA | Chemotherapy | In vitro | [114] |
| DOTAP | Ethanol injection | siRNA and miRNA | Chemotherapy | In vitro and In vivo | [28] |