Figure 1.

Significant reduction in tremor severity was measured clinically and objectively, and improvements in arm functionality and quality of life were observed over the 30-week treatment course. Mean clinical scores for the Fahn-Tolosa-Marin part A (A), part B and C (B), Quality of Life (C) scales, mean angular root mean square tremor amplitudes at the wrist (D), elbow (E), and shoulder (F), perceived weakness Likert scale (G), and mean maximal grip strength (H) in both upper limbs. “Motor-dom” indicates the motor-dominant arm and “non-motor dom” indicates non-motor dominant arm of all participants. Asterisks (*) represent statistical significance in means compared to week 0, or comparisons otherwise stated by a line, and asterisk colors are coordinated with each line plot. Injections were administered every 12 weeks starting at week 0.