Table 1.
The significant differentially expressed (DE) messenger RNA (mRNAs) as determined by DESeq2 (false discovery rate, FDR < 0.1) using ex vivo human skin samples treated with TGFβ or a vehicle control for 48 h. The top 100 most significant DE mRNAs ranked by FDR (padj) are presented.
| Symbol | GeneID | Description | Padj | Fold Change |
|---|---|---|---|---|
| COL22A1 | 169044 | collagen, type XXII, alpha 1 | 6.40 × 10−36 | 9.19 |
| PMEPA1 | 56937 | prostate transmembrane protein, androgen induced 1 | 6.36 × 10−33 | 3.51 |
| DPT | 1805 | dermatopontin | 2.89 × 10−29 | 4.69 |
| LTBP2 | 4053 | latent transforming growth factor beta binding protein 2 | 6.31 × 10−26 | 3.18 |
| COL1A1 | 1277 | collagen, type I, alpha 1 | 2.49 × 10−23 | 3.11 |
| FN1 | 2335 | fibronectin 1 | 2.78 × 10−20 | 3.39 |
| MMP10 | 4319 | matrix metallopeptidase 10 | 6.47 × 10−13 | 2.76 |
| COL3A1 | 1281 | collagen, type III, alpha 1 | 5.68 × 10−12 | 2.34 |
| DHRS2 | 10202 | dehydrogenase/reductase (SDR family) member 2 | 6.16 × 10−12 | 4.55 |
| COL5A2 | 1290 | collagen, type V, alpha 2 | 8.53 × 10−12 | 2.36 |
| ITGB6 | 3694 | integrin, beta 6 | 1.66 × 10−11 | 2.94 |
| ADAMTS15 | 170689 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | 1.77 × 10−11 | 3.55 |
| LRRC15 | 131578 | leucine rich repeat containing 15 | 1.77 × 10−11 | 4.17 |
| TGFBI | 7045 | transforming growth factor, beta-induced, 68kDa | 6.21 × 10−11 | 3.12 |
| MKI67 | 4288 | marker of proliferation Ki-67 | 7.29 × 10−11 | −2.56 |
| COL1A2 | 1278 | collagen, type I, alpha 2 | 8.85 × 10−11 | 2.11 |
| ADAM12 | 8038 | ADAM metallopeptidase domain 12 | 3.00 × 10−10 | 2.71 |
| GLS | 2744 | glutaminase | 3.08 × 10−10 | 2.08 |
| MIAT | 440823 | myocardial infarction associated transcript (non-protein coding) | 3.36 × 10−10 | 3.23 |
| C4orf26 | 152816 | chromosome 4 open reading frame 26 | 3.59 × 10−10 | 4.07 |
| WNT5B | 81029 | wingless-type MMTV integration site family, member 5B | 1.01 × 10−9 | 3.58 |
| KRT77 | 374454 | keratin 77, type II | 3.56 × 10−9 | 2.19 |
| CXCL14 | 9547 | chemokine (C-X-C motif) ligand 14 | 7.49 × 10−9 | 2.61 |
| TPST1 | 8460 | tyrosylprotein sulfotransferase 1 | 8.75 × 10−9 | 2.58 |
| COL15A1 | 1306 | collagen, type XV, alpha 1 | 1.03 × 10−8 | 2.75 |
| SNAI1 | 6615 | snail family zinc finger 1 | 1.04 × 10−8 | 2.65 |
| NKD1 | 85407 | naked cuticle homolog 1 (Drosophila) | 2.62 × 10−8 | 3.41 |
| LDLRAD4 | 753 | low density lipoprotein receptor class A domain containing 4 | 1.43 × 10−7 | 3.30 |
| NPR3 | 4883 | natriuretic peptide receptor 3 | 1.46 × 10−7 | 2.96 |
| DHRS9 | 10170 | dehydrogenase/reductase (SDR family) member 9 | 1.64 × 10−7 | −2.44 |
| COL5A1 | 1289 | collagen, type V, alpha 1 | 2.11 × 10−7 | 2.11 |
| ESM1 | 11082 | endothelial cell-specific molecule 1 | 2.11 × 10−7 | 2.83 |
| DIRAS1 | 148252 | DIRAS family, GTP-binding RAS-like 1 | 2.17 × 10−7 | 2.51 |
| DLGAP5 | 9787 | discs, large (Drosophila) homolog-associated protein 5 | 3.77 × 10−7 | −2.66 |
| RRM2 | 6241 | ribonucleotide reductase M2 | 7.85 × 10−7 | −2.46 |
| TPM1 | 7168 | tropomyosin 1 (alpha) | 7.85 × 10−7 | 2.55 |
| VCAN | 1462 | versican | 8.57 × 10−7 | 2.42 |
| CENPF | 1063 | centromere protein F, 350/400kDa | 9.28 × 10−7 | −2.54 |
| CEP55 | 55165 | centrosomal protein 55kDa | 1.84 × 10−6 | −2.49 |
| SOX9 | 6662 | SRY (sex determining region Y)-box 9 | 1.84 × 10−6 | 1.93 |
| HECW2 | 57520 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | 2.00 × 10−6 | 2.61 |
| PRSS23 | 11098 | protease, serine, 23 | 2.00 × 10−6 | 2.44 |
| SPRR2D | 6703 | small proline-rich protein 2D | 2.42 × 10−6 | −1.78 |
| GADD45B | 4616 | growth arrest and DNA-damage-inducible, beta | 2.70 × 10−6 | 1.98 |
| KIF4A | 24137 | kinesin family member 4A | 2.84 × 10−6 | −2.55 |
| CACNA1C | 775 | calcium channel, voltage-dependent, L type, alpha 1C subunit | 2.87 × 10−6 | 2.69 |
| LARP6 | 55323 | La ribonucleoprotein domain family, member 6 | 3.68 × 10−6 | 2.23 |
| MMP13 | 4322 | matrix metallopeptidase 13 | 3.83 × 10−6 | 3.02 |
| FGFBP2 | 83888 | fibroblast growth factor binding protein 2 | 5.18 × 10−6 | 2.93 |
| TOP2A | 7153 | topoisomerase (DNA) II alpha 170kDa | 6.21 × 10−6 | −2.37 |
| DNAH17 | 8632 | dynein, axonemal, heavy chain 17 | 7.27 × 10−6 | 1.98 |
| IL11 | 3589 | interleukin 11 | 8.58 × 10−6 | 2.68 |
| EREG | 2069 | epiregulin | 9.06 × 10−6 | −2.16 |
| PHLDB1 | 23187 | pleckstrin homology-like domain, family B, member 1 | 9.42 × 10−6 | 1.95 |
| IQGAP3 | 128239 | IQ motif containing GTPase activating protein 3 | 9.76 × 10−6 | −2.42 |
| A2ML1 | 144568 | alpha-2-macroglobulin-like 1 | 9.83 × 10−6 | −1.84 |
| NDC80 | 10403 | NDC80 kinetochore complex component | 1.02 × 10−5 | −2.57 |
| TROAP | 10024 | trophinin associated protein | 1.20 × 10−5 | −2.45 |
| CDCA8 | 55143 | cell division cycle associated 8 | 1.40 × 10−5 | −2.24 |
| TRIP13 | 9319 | thyroid hormone receptor interactor 13 | 1.89 × 10−5 | −2.33 |
| GPRC5A | 9052 | G protein-coupled receptor, class C, group 5, member A | 2.19 × 10−5 | 2.37 |
| ARL15 | 54622 | ADP-ribosylation factor-like 15 | 2.51 × 10−5 | 2.32 |
| CDC20 | 991 | cell division cycle 20 | 2.68 × 10−5 | −2.48 |
| BIRC5 | 332 | baculoviral IAP repeat containing 5 | 2.69 × 10−5 | −2.34 |
| LYPD1 | 116372 | LY6/PLAUR domain containing 1 | 2.81 × 10−5 | 2.77 |
| DCLK3 | 85443 | doublecortin-like kinase 3 | 2.91 × 10−5 | 2.78 |
| AURKB | 9212 | aurora kinase B | 2.91 × 10−5 | −2.28 |
| MYBL2 | 4605 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 3.49 × 10−5 | −2.09 |
| MFAP2 | 4237 | microfibrillar-associated protein 2 | 3.53 × 10−5 | 1.88 |
| WNT2 | 7472 | wingless-type MMTV integration site family member 2 | 3.53 × 10−5 | 2.76 |
| S100A7A | 338324 | S100 calcium binding protein A7A | 3.77 × 10−5 | −2.12 |
| NREP | 9315 | neuronal regeneration related protein | 3.86 × 10−5 | 1.92 |
| PKMYT1 | 9088 | protein kinase, membrane associated tyrosine/threonine 1 | 4.74 × 10−5 | −2.07 |
| HMCN2 | 256158 | hemicentin 2 | 5.10 × 10−5 | 2.69 |
| CDC45 | 8318 | cell division cycle 45 | 5.23 × 10−5 | −2.05 |
| TICRR | 90381 | TOPBP1-interacting checkpoint and replication regulator | 6.00 × 10−5 | −2.40 |
| SETBP1 | 26040 | SET binding protein 1 | 6.31 × 10−5 | 1.87 |
| TPX2 | 22974 | TPX2, microtubule-associated | 6.31 × 10−5 | −2.25 |
| KIFC1 | 3833 | kinesin family member C1 | 6.49 × 10−5 | −2.27 |
| CDCA5 | 113130 | cell division cycle associated 5 | 6.62 × 10−5 | −2.12 |
| PRICKLE1 | 144165 | prickle homolog 1 (Drosophila) | 7.37 × 10−5 | 2.23 |
| LBH | 81606 | limb bud and heart development | 8.71 × 10−5 | 2.31 |
| CCL28 | 56477 | chemokine (C-C motif) ligand 28 | 8.81 × 10−5 | 2.48 |
| FAM150B | 285016 | family with sequence similarity 150, member B | 8.81 × 10−5 | 2.65 |
| SKA3 | 221150 | spindle and kinetochore associated complex subunit 3 | 9.14 × 10−5 | −2.41 |
| PRC1 | 9055 | protein regulator of cytokinesis 1 | 9.24 × 10−5 | −2.12 |
| TACC3 | 10460 | transforming, acidic coiled-coil containing protein 3 | 9.34 × 10−5 | −1.96 |
| KIF18B | 146909 | kinesin family member 18B | 1.05 × 10−4 | −2.25 |
| CD83 | 9308 | CD83 molecule | 1.09 × 10−4 | 2.07 |
| TMEM86A | 144110 | transmembrane protein 86A | 1.09 × 10−4 | −1.88 |
| RUNX1 | 861 | runt-related transcription factor 1 | 1.18 × 10−4 | 1.99 |
| ATP12A | 479 | ATPase, H+/K+ transporting, nongastric, alpha polypeptide | 1.25 × 10−4 | −2.26 |
| MAP1B | 4131 | microtubule-associated protein 1B | 1.25 × 10−4 | 1.71 |
| BGN | 633 | biglycan | 1.30 × 10−4 | 2.43 |
| PNMAL1 | 55228 | paraneoplastic Ma antigen family-like 1 | 1.31 × 10−4 | 2.25 |
| TK1 | 7083 | thymidine kinase 1, soluble | 1.42 × 10−4 | −2.08 |
| BMP6 | 654 | bone morphogenetic protein 6 | 1.46 × 10−4 | 2.19 |
| HPSE | 10855 | heparanase | 1.61 × 10−4 | −1.77 |
| SEMA7A | 8482 | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) | 1.73 × 10−4 | 1.78 |
| CCL8 | 6355 | chemokine (C-C motif) ligand 8 | 1.82 × 10−4 | −2.56 |