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. 2019 Feb 2;11(2):65. doi: 10.3390/pharmaceutics11020065

Figure 4.

Figure 4

Biodistribution of functionalized ddMTX-loaded SLNs and free MTX (sacrifice 3 h after administration): in (A) the whole body and (B) brain and capillary depletion (cap. dep.). Statistical analysis: ddMTX-loaded SLNs vs. free MTX; SLNs < MTX: p < 0.01 £ SLNs INS ST-PEG-MBS < MTX: p < 0.05 *; SLNs INS ST-MBS < MTX: p < 0.01 $, p < 0.05 $$; SLNs > MTX: p < 0.1 #, p < 0.05 ##; SLNs TRF ST-PEG-MBS > MTX: p < 0.1 §, p < 0.05 §§, p < 0.01 §§§; SLNs INS ST-PEG-MBS>MTX: p < 0.1 °, p < 0.05 °°; SLNs TRF ST-MBS > MTX: p < 0.1, ST-MBS > MTX: p < 0.1 @.