Scheme 1.
Synthesis of GQD-PEG-BFG. Reagents and conditions: (a) Boc-NH-PEG-NH2, EDC⋅HCl, HOBt, ETA, DMAP, DMF, 4 d, r.t., then, HCl 4 M, dioxane, 1 h, r.t.; (b) BFG, KOtBu, air. H2O/THF, 1 h, r.t.
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