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Domains and ternary structure of Lachnospiraceae bacterium ND2006 Cas12a (PDB: 5xus, TTTA PAM) [11]. Locations of “finger”, “linker” and “lid” from Stella et al. [8]; note that the “lid” is not resolved in PDB: 5xus. The putative path of the non-target strand (NTS) is shown on the structure as a thick dotted line, with the arrowhead pointing towards the RuvC active site.
