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Schematic representation of MgO-DOX TDD system: Electrostatic interactions and hydrogen bonds facilitating binding of DOX on to MgO surface (a) and drug and Mg2+ slow release at slightly acidic conditions prevailing in cancer cells (b). After slow diffusion of MgO nano flakes from blood vessel to cancer cell, DOX molecules interact with mutated DNA and Mg2+ act as a nutrient to hypomagnesemia (c).
