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. 2019 Feb 22;10(2):170. doi: 10.3390/genes10020170

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Roles of FANCJ in the replication stress response. (A) FANCJ facilitates homology-directed repair of DSBs or ICL-induced broken replication forks. (B) FANCJ resolves G-quadruplex structures formed at transient single-stranded DNA regions during replication or possibly transcription. (C) FANCJ unwinds hairpin duplexes formed in single-stranded DNA templates during replication fork progression through repetitive DNA sequences of the genome thereby suppressing microsatellite instability. (D) FANCJ promotes DNA synthesis at stalled replication forks to minimize HLTF-mediated fork regression and prevent fork degradation.