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. 2019 Jan 24;9(2):147. doi: 10.3390/nano9020147

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis schematics for the PAMAM dendrimer nanocomposites. (a) Synthesis of pegylated PAMAM dendrimer (mPEG-PAMAM G5.NH₂); (b) synthesis of mPEG-PAMAM G5.NHAc by the addition reaction between anhydride and the amino group; (c) paeonol (PAE) loading in the cavities of mPEG-PAMAM G5.NHAc; (d) the FITC tracer was used to label PAMAM to observe the nasal brain transport of PAMAM dendrimer nanocomposite in vivo.