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The therapeutic efficacy of M-MTX/siRNA in vivo. The tumor volume (A), photographs of the solid tumor (B), the tumor weight (C) of the animals treated with various drug formulations were obtained on day 24. (n = 5, ** p < 0.01, M-MTX/siRNA compared to saline). The body weight of the tumor-bearing mice treated with various drug formulations was also measured to assess the system toxicity (D). The values are the mean ± SEM, n = 5.
