Table 5.
Overview of peptide toxins found in nemerteans.
| ID | Toxin | Species | Geographic Origin | Function | Ref |
|---|---|---|---|---|---|
| Pore-forming/hemolytic | |||||
| - | Cytotoxin A-I a | Cerebratulus lacteus | Woods hole, MA, USA | Pore-forming; hemolytic | [5,104] |
| - | Cytotoxin A-II a | Cerebratulus lacteus | Woods hole, MA, USA | Pore-forming; hemolytic | [5,104] |
| P01527 | Cytotoxin A-III a | Cerebratulus lacteus | Woods hole, MA, USA | Pore-forming; hemolytic | [5,104] |
| - | Cytotoxin A-IV a | Cerebratulus lacteus | Woods hole, MA, USA | Pore-forming; hemolytic | [104] |
| 6ENA b | Nemertide α-1 | Lineus longissimus | Koster Fiord, Swe | VGSC activator, paralytic | [120] |
| - | Nemertide α-2 | Lineus longissimus | Koster Fiord, Swe | Likely VGSC activator, paralytic | [120] |
| - | Nemertide β-1 | Lineus longissimus | Koster Fiord, Swe | Neurotoxin B-IV homolog. Likely paralytic. | [120] |
| - | ”Nemertine” | Lineus ruber | Possible nemertide | [5] | |
| - | ”Nemertine” | Tenuilineus bicolor f | Not stated | Possible nemertide | [5] |
| - | ”Nemertine” | Lineus viridis | Not stated | Possible nemertide | [5] |
| - | <5 kDa component | Lineus longissimus | Koster Fiord, Swe, and Millport Scot, UK | Paralytic. Likely α-nemertide | [25] |
| - | Neurotoxin B-I c | Cerebratulus lacteus | Long Island Sound, NY, USA | Likely paralytic | [89] |
| P01526 | Neurotoxin B-II c | Cerebratulus lacteus | Long Island Sound, NY, USA | Paralytic | [89] |
| P01526 | Neurotoxin B-II | Cerebratulus lacteus | Woods hole, MA, USA | Paralytic | [104] |
| - | Neurotoxin B-III c | Cerebratulus lacteus | Long Island Sound, NY, USA | Likely paralytic | [89] |
| P01525 | Neurotoxin B-IV | Cerebratulus lacteus | Woods hole, MA, USA | Paralytic | [104] |
ID is short for UniProtKB entry (uniprot.org). a In source referred to as Cerebratulus toxin A (I-IV). b PDB code. c In source referred to as Cerebratulus toxin B (I-IV). Species are denoted according to WoRMS, World Register of Marine Species as of 19-02-11 [54].