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. 2019 Feb 15;11(2):81. doi: 10.3390/pharmaceutics11020081

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Imaging-guided drug delivery of NP-AAG in both mouse models bearing (a) subcutaneous and (b) orthotopic PC3 xenograft. In vivo and ex vivo white light (WL) and NIRF imaging of nude mice bearing subcutaneous PC3 xenograft (a) or orthotopic PC3 xenograft (b) 72 h post-injection of NP-AAG. Arrows: tumor site. (c) Analysis of NIRF imaging on each tumor and organs after normalization to the fluorescence of muscle. Reproduced from Reference [52] (Theranostics 06: 1324 image No. 006, open access policy).