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Phylogeny of select HAdV and SAdV ITRs. Recent host-adapted HAdV-E4, including Hong Kong isolates, subclade with HAdVs. Prototype-like HAdV-E4 isolates subclade with SAdVs. Inverted terminal repeats (ca., 116 bases) were aligned using Molecular Evolutionary Genetics Analysis (MEGA) 7.0.26 software (https://www.megasoftware.net), and phylogenetic trees were constructed with a maximum-likelihood method incorporating 1000 bootstrap replications.
