Table 1.
Liposome composition (mass ratio) and characterization parameters. Encapsulation efficiency percentage (EE%) of cefepime into these liposomes. α represents molar ratio between the cationic lipid and the total lipid (Errors in EE% were always lower than 10%). Pdi: polydispersity index.
| Liposomes | SAMPLE | Mass Ratio | Mol Ratio | α | ζ/mV | Size/nm | Pdi | EE% |
|---|---|---|---|---|---|---|---|---|
| PC:CH | A | 5.3:1 | 2.5:1 | - | −24 ± 1 | 117 ± 9 | 0.1 | 17 |
| B | 1.2:1 | 0.6:1 | - | −29 ± 1 | 121 ± 8 | 0.2 | 19 | |
| PC:CH: 12NBr | C | 21:1:1.5 | 10:1:1.2 | 0.14 | +45 ± 1 | 138 ± 24 | 0.1 | 27 |
| D | 32:1:3.5 | 15:1:2.5 | 0.19 | +42 ± 2 | 121 ± 13 | 0.2 | 43 | |
| E | 7.6:1:1.5 | 3.6:1:1 | 0.25 | +54 ± 4 | 104 ± 12 | 0.1 | 3 | |
| F | 16:1:3.5 | 7.5:1:3 | 0.35 | +48 ± 2 | 111 ± 14 | 0.2 | 13 | |
| DOPE:12NBr | G | 1:1.6 | 1:2.5 | 0.20 | +30 ± 1 | 107 ± 15 | 0.2 | 6 |
| H | 1:2.8 | 1:4.2 | 0.30 | +28 ± 1 | 114 ± 14 | 0.3 | 6 | |
| I | 1:4.4 | 1:6.7 | 0.40 | +31 ± 1 | 100 ± 15 | 0.2 | 2 | |
| J | 1:15 | 1:23 | 0.70 | +32 ± 4 | 140 ± 28 | 0.3 | 8 | |
| K | 1:25 | 1:38 | 0.80 | +37 ± 2 | 107 ± 12 | 0.2 | 7 |