DE lncRNAs, targeted genes and DEGs were composed of the interactive network. The red and green colors represent up and down regulation, the quadrilateral, box and circles represent lncRNAs, targeted genes and DE genes, the straight line and dotted line represent the interaction relationship between trans- and cis-regulation respectively. GPR179, G protein-coupled receptor 179; CACNB2, calcium voltage-gated channel auxiliary subunit β 2; SREBF1, sterol regulatory element binding transcription factor 1; SMG1, suppressor of morphogenesis in genitalia 1; LRFN3, leucine rich repeat and fibronectin type III domain containing 3; SORT1, sortilin 1; PSMA5, proteasome subunit α 5; SMAD2, SMAD family member 2; FOSB, FosB proto-oncogene, AP-1 transcription factor subunit; EFNB3, ephrin B3; ADCY6, adenylate cyclase 6; L1CAM, L1 cell adhesion molecule; IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon; ALCAM, activated leukocyte cell adhesion molecule; GLUL, glutamate-ammonia ligase; RORA, RAR related orphan receptor A; BDNF, brain derived neurotrophic factor; MYLK3, myosin light chain kinase 3; SIK2, salt inducible kinase 2; CTNND2, catenin delta 2; SP3, Sp3 transcription factor; SEMA3A, semaphorin 3A; PTPRN, protein tyrosine phosphatase, receptor type N; NCOA6, nuclear receptor coactivator 6; FOXP1, forkhead box P1; ROBO1, roundabout guidance receptor 1; BAG3, BCL2 associated athanogene 3; GRIK2, glutamate ionotropic receptor kainate type subunit 2; BRAF, B-Raf proto-oncogene, serine/threonine kinase; RB1, RB transcriptional corepressor 1; MDM4, MDM4, p53 regulator; MAGI3, membrane associated guanylate kinase, WW and PDZ domain containing 3.