Figure 2.

KDM4B integrates multiple cellular signals to affect biological processes. KDM4B is induced by multiple different extracellular stimuli. The majority of studies regarding its function describe it as an activator that removes repressive H3K9me3 and H3K9me2 at or near regulated promoters in order to facilitate expression of the indicated pathways. Representative target genes (if known) are shown in each pathway.