Table 1.

Summary of medical management used to treat cystic fibrosis rhinosinusitis.

Reference	Therapeutic	Duration	Outcome
Cimmino et al. [24]	Dornase-alpha	48 weeks	Improved sinonasal symptoms, LKNE score, LMS, and FEV1
Mainz et al. [25]	Dornase-alpha	4 weeks	Improved SNOT-22 and forced expiratory flow 75%–25%
Mainz et al. [26]	Isotonic vs. hypertonic saline	4 weeks	Both led to similar small improvements in SNOT-22
Hadfield et al. [28]	Beclomethasone	6 weeks	Reduction in polyposis but no change in symptom score
Donaldson et al. [29]	Beclomethasone	Not described	Improvement in nasal polyposis and nasal obstruction
Aanaes et al. [35]	Colistin irrigations	6 months	Negative sinus cultures for at least 6 months in at least 50% of patients
Mainz et al. [36]	Nebulized tobramycin	4 weeks–8 weeks	Decreased burden of P. aeruginosa and improvement in SNOT-22
Moss et al. [37]	Tobramycin lavage	7–10 days (with repetitive treatments if necessary)	Improved reoperation rate for endoscopic sinus surgery
Chang et al. [38]	Ivacaftor	10 months	Improved symptoms and FEV1
Lindstrom et al. [40]	Ibuprofen	Unknown	Temporary resolution of nasal polyps with >50% of patients experiencing recurrence

Abbreviations, LKNE: Lund–Kennedy Nasal Endoscopy, LMS: Lund–Mackay score, FEV1: forced expiratory volume in 1 s, SNOT-22: Sinonasal Outcome Test-22.