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. 2019 Feb 6;11(2):96. doi: 10.3390/toxins11020096

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Electron micrograph of the myocardium from (A) control mice (left panel), and from (B) mice treated daily with 125 µg/kg TTX. Note the different magnifications shown. Scale bar is 10 µm, 5 µm, 2 µm, and 1 µm respectively, from top to bottom panels. Mc: myocardial cells, S: sarcolemma, Id: intercalated disk, Sr: sarcoplasmic reticulum, M: mitochondria, Mf: myofibrils. Evident multifocal vacuolization, sarcoplasmatic dilation, and disintegration of myofibrils (arrows in the bottom right panel) were observed in the heart of TTX-treated mice.