Table 2.
Effect of repeated exposure of mice to TTX on body weight (BW)and accumulated weight change during the 28 day treatment period. Values are expressed as mean ± SEM, except for the dose of 75 µg/kg, where results represent the mean (n = 2).
| Group | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 |
|---|---|---|---|---|---|
| Control | (n = 5) | (n = 5) | (n = 5) | (n = 5) | (n = 5) |
| Body weight (g) | 20.2 ± 0.5 | 20.6 ± 0.5 | 23.2 ± 1 | 23.5 ± 1.5 | 23.3 ± 2.1 |
| Cumulative BW (g) | 0.0 | 0.4 ± 0.6 | 3.0 ± 1.0 | 3.4 ± 1.5 | 3.2 ± 2.1 |
| 25 µg/kg TTX | (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) |
| Body weight (g) | 19.8 ± 0.5 | 20.7 ± 1.2 | 21.9 ± 1.1 | 22.2 ± 0.9 | 22.7 ± 0.5 |
| Cumulative BW (g) | 0.0 | 0.9 ± 0.9 | 2.1 ± 0.7 | 2.4 ± 0.8 | 2.9 ± 0.3 |
| 75 µg/kg TTX | (n = 4) | (n = 2) | (n = 2) | (n = 2) | (n = 2) |
| Body weight (g) | 19.0 ± 0.6 | 19.8 | 21 | 22.1 | 23.0 |
| Cumulative BW (g) | 0.0 | 0.7 | 1.9 | 3.1 | 3.9 |
| 125 µg/kg TTX | (n = 5) | (n = 4) | (n = 3) | (n = 3) | (n = 3) |
| Body weight (g) | 20.5 ± 0.2 | 18.6 ± 0.3 | 18.9 ± 0.5 | 19.1 ± 0.5 | 19.4 ± 0.4 |
| Cumulative BW(g) | 0.0 | −1.9 ± 0.4 | −1.6 ± 0.5 | −1.3 ± 0.5 | −1.1 ± 0.4 |