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X-ray crystal structure of NV 3CLPro and GC543 (A,C, PDB: 4XBC) and GC583 (B,D, PDB: 4XBB). The structures revealed that increased potency is correlated to interactions between the S4 subsite and the cap residue. The m-Cl benzyl group in the cap allows for interactions with hydrophobic residues in S4.
