Figure 1.
Effect of gukulenin A on tumor growth in a mouse xenograft model. (A) Chemical structure of gukulenin A isolated from the marine sponge Phorbas gukhulensis. (B–D) A2780 xenografts were treated with vehicle or gukulenin A (1 and 3 mg/kg) every three days for 15 days. (B) At day 15, the mice were sacrificed and tumor weights (g) were measured. Tumor volume (mm3) (C) and body weight (D) changes were measured every three days for 15 days. The data are expressed as means ± SD (n = 5). * p < 0.05 as compared with the vehicle-treated group.