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. Author manuscript; available in PMC: 2019 Mar 11.
Published in final edited form as: Nat Med. 2017 Oct 9;23(11):1298–1308. doi: 10.1038/nm.4412

Figure 2.

Figure 2

Intestine-specific HIF-2α disruption ameliorates the development of hepatic steatosis. (a) Representative H&E staining (left two panels) and Oil Red O staining (right two panels) of liver sections (n = 5 mice/group, 3 images/mouse). Scale bars, 100 μm. (b) Liver weights. (c) Liver weight–to–body weight ratios. (d,e) Liver (d) and serum (e) triglyceride content. (f,g) Liver (f) and serum (g) cholesterol content. (h) Serum ALT levels. (i) Hepatic expression of mRNAs encoded by hepatic fatty acid transport and lipogenesis-related genes. (j) Hepatic expression of mRNAs encoded by hepatic fatty acid β-oxidation-related genes. (k) Hepatic expression of mRNAs encoded by inflammatory cytokine and chemokine genes. HFD-fed Hif2afl/fl and Hif2aΔIE mice. n = 5/group. For box plots, the midline represents the median; box represents the IQR between the first and third quartiles, and whiskers represent the lowest or highest values within 1.5 times IQR from the first or third quartiles. *P < 0.05, **P < 0.01 relative to Hif2afl/fl mice, by two-tailed Student’s t-test.