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. 2019 Feb 25;2019:8639791. doi: 10.1155/2019/8639791

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Copyright © 2019 Yu Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MnTE-2-PyP reverses the expression of MMP-2 and MMP-9 induced by TGF-β. (a) The positive correlation between TGF-β and MMP-2 transcript levels in GSE17538. (b) The positive correlation between TGF-β and MMP-9 transcript levels in GSE17538. (c, d) PCR and western blot analysis showed that TGF-β induced MMP-2 and MMP-9 mRNA levels in SW480 cells. The treatment of the cells with MnTE-2-PyP markedly inhibited TGF-β-induced MMP-2 and MMP-9. ^∗P < 0.05 compared to the control group. (e) Kaplan-Meier curves indicating the overall survival in GSE17538 with low or high levels of MMP-2 (cutoff value = 9.77). (f) Kaplan-Meier curves indicating the overall survival in GSE17538 with low or high levels of MMP-9 (cutoff value = 8.52).